There is a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to decrease afferent soreness transmission and produce analgesia. For that reason, prescription drugs like clonidine that concentrate on alpha-2 receptors can influence the transmission of pain. Applies to clonidine: https://bookmarkquotes.com/story19842815/the-2-minute-rule-for-onolidine