There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to reduce afferent ache transmission and produce analgesia. Hence, medication like clonidine that target alpha-2 receptors can affect the transmission of ache. Severe Allergic Reactions. Clonidine may possibly trigger https://www.proleviate.com/post/the-new-pain-killer-conolidine