Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals within the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, that... https://bjorka974tbi1.blogs100.com/profile