Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor cell-microenvironment interact... https://ashleighr370fmu1.wikififfi.com/user