At the moment, There are 2 kinds of experiments on itaconate: Irg1−/− macrophages along with the regulatory outcome of itaconate derivatives. These two success were being complementary and discovered that the regulatory mechanisms of itaconate included alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription aspect three (ATF3) https://s--crizotinib11097.blogkoo.com/thiamet-g-an-overview-49358989