Ketoconazole Coadministration of bosentan a hundred twenty five mg two times every day and ketoconazole, a powerful CYP3A inhibitor, increased the plasma concentrations of bosentan by about a hundred% in normal volunteers. No dose adjustment of bosentan is critical, but greater effects of bosentan need to be deemed. The affected https://knoxvaurm.wssblogs.com/26115422/bosentan-an-overview